DIPEPTIDES N-ACETYLES ET NON ACETYLES CONTENANT DE L'ARGININE DESTINES A REDUIRE LA VISCOSITE DE COMPOSITIONS VISQUEUSES DE POLYPEPTIDES THERAPEUTIQUES
AGRAWAL, NEERAJ JAGDISH,GHATTYVENKATAKRISHNA, PAVAN,KANAPURAM, SEKHAR,SLOEY, CHRISTOPHER JAMES
申请号：
CA3059369
公开号：
CA3059369A1
申请日:
2018.04.27
申请国别(地区):
CA
年份:
2018
代理人:
摘要：
Provided herein are excipients capable of effectively reducing the viscosity of polypeptide (e.g., therapeutic polypeptide) formulations. The viscosity reducing excipients are dipeptides containing arginine at the carboxy terminus and N-acetylated serine or N-acetylated proline at the N-terminus. Glutamate-arginine is also disclosed as a viscosity-reducing dipeptide. Among the disclosed methods, methods of reducing the viscosities of such formulations are also provided.
