Agrawal, Neeraj Jagdish,Ghattyvenkatakrishna, Pavan,Kanapuram, Sekhar,Sloey, Christopher James
申请号：
AU2018258676
公开号：
AU2018258676A1
申请日:
2018.04.27
申请国别(地区):
AU
年份:
2019
代理人:
摘要：
Provided herein are excipients capable of effectively reducing the viscosity of polypeptide (e.g., therapeutic polypeptide) formulations. The viscosity reducing excipients are dipeptides containing arginine at the carboxy terminus and N-acetylated serine or N-acetylated proline at the N-terminus. Glutamate-arginine is also disclosed as a viscosity-reducing dipeptide. Among the disclosed methods, methods of reducing the viscosities of such formulations are also provided.
