MATTHEWS, DAVID JOHN,BARLOW, JILLIAN,MCKENZIE, ANDREW NEIL JAMES,MATTHEWS, David John,BARLOW, Jillian,MCKENZIE, Andrew Neil James
申请号：
RSP20150341
公开号：
RS54028B1
申请日:
2009.09.30
申请国别(地区):
RS
年份:
2015
代理人:
摘要：
The present invention relates to IL-25 antibody VH domains and target binding members (e.g., antibodies) that comprise such antibody VH domains and bind IL-25. The invention also relates to compositions comprising target binding members {e.g., antibodies) that bind IL-25, methods of producing such target binding members, and uses of such target binding members for the treatment or prevention of diseases and conditions (e.g., asthma, inflammatory bowel disease).Član za vezivanje cilja koji vezuje IL-25, koji obuhvata VL domen antitela koji obuhvata Kabat CDR-e 1-3 kakvi postoje u ostacima 24=34 (SEQ ID NO:29)； 50-56 (SEQ ID NO:30) i 89-97 (SEQ ID NO:31), posebno od SEQ ID NO:15 i VH domen antitela koji obuhvata SEQ ID NO:1:Glu Val Gln Leu Val Glu Ser Gly Ala Glu Val Lys Lys Pro Gly Ala Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Ser Phe Xa1 Xa2 Tyr Thr Met Asn Trp Val Arg Gln Ala Pro Gly Gln Arg Leu Glu Trp Xa3 Gly Leu Ile Asn Pro Tyr Asn Gly Gly Thr Ser Tyr Asn Gln Asn Phe Lys Gly Arg Val Thr Leu Thr Xa4 Asp Thr Ser Ala Ser Thr Ala Tyr Leu Glu Leu Asn Ser Leu Arg Ser Glu Asp Thr Gly Val Tyr Tyr Cys Ala Arg Glu Xa5 Tyr Asp Gly Tyr Leu Tyr Phe Ala Met Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Sergde:Xa1 je Ser ili Thr；Xa2 je Gly, Asp, Ala, Ser, Val, Asn, Lys, Tyr ili Met；Xa3 je Met ili Ile；Xa4 je Val ili Arg； iXa5 je Asp, Asn ili Gly.Prijava sadrži još 14 patentnih zahteva.
