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Application of glucose-2 cucumber (GLP-2) analysis method
专利权人:
ZEALAND PHARMA A/S
发明人:
SONNE, Kim,MOURITZEN, Ulrik,GLERUP, Peter,JEPPESEN, Palle Bekker
申请号:
PE2019002548
公开号:
PE20200678A1
申请日:
2018.06.15
申请国别(地区):
PE
年份:
2020
代理人:
摘要:
It refers to the cucumber analysis of a glucose-2 (GLP-2),The following formula represents: r1-z1-z1-his-gly-gly-glu-gly-gly-x5-phe-ser-ser-ser-glu-leu- leu-x11-thr-lle-leu-asp-ala-arg-asp-asp-asp-asp-asp-asp-asp-arg-asp-asp-asp-z2-r2: r1-z1-his-his-gly-gly-gly-glu-gly-gly-gly-gly-gly-gly-gly-gly-gly-gly-gly-gly-gly-gly-gly-gly-gly-gly-gly-x5 is represented by the following formula: r1-z1-z1-x5-phe-ser-ser-ser-ser-ser-glu-leu-leu-leu-ala-arg-arg-substituted diphenyl; ilo-x5 as trioxy or pentabromodiphenyl or pentabromodiphenyl or sulfur trifluoride; as trioxytoluene or pentabromodiphenyl or pentabromodiphenyl or either, or is, or isZ1 and Z2 are independently absent or are a Lys carbamate consisting of 1-6 units. This glucose-2 cucumber assay is useful for the treatment and / or prevention of gastric and intestinal disorders and for enhancing the side effects of chemotherapy and radiotherapy. He also mentioned posology for administrationSe refiere a un analogo de peptido de tipo glucagon 2 (GLP-2), representado por la formula: R1-Z1-His-Gly-Glu-Gly-X5-Phe-Ser-Ser-Glu-Leu-X11-Thr-lle-Leu-Asp-Ala-Leu-Ala-Ala-Arg-Asp-Phe-lle-Ala-Trp-Leu-lle-Ala-Thr-Lys-lle-Thr-Asp-Z2-R2, en la que : R1 es hidrogeno, alquilo de C1-4, acetilo, formilo, benzoilo o trifluoroacetilo; X5 es Ser o Thr; X11 es Ala o Ser; R2 es NH2 u OH; y Z1 y Z2 estan independientemente ausentes o son una secuencia peptidica de 1-6 unidades de aminoacidos de Lys. Dicho analogo de peptido de tipo glucagon 2 (GLP-2) es util en el tratamiento y/o prevencion de un trastorno relacionado con el estomago y el intestino y para mejorar los efectos secundarios de quimioterapia y radioterapia. Tambien se refiere a posologias para la administracion
来源网站:
中国工程科技知识中心
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