Analysis of exendina-4 peptide (a peptide similar to type 1 glucose / Glucose dependent insulin cholesterol) as a dual effect drug of GLP-1 / GIP receptor
This refers to exendin-4 derivative and its medical use, for example, in the treatment of disorders of the metabolic syndrome, including Obesity and diabetes, in addition to reducing the excessive intake of food.Claim 1: a Peptide Compound with the formula (1): r u00b9 R u00b2 - Z - (1) where z is a Peptide that has the rest of formula (2): AIB Tyr Glu Gly THR Phe - Thr - - - - be ASP Leu ile GLN x u00b9 u2074 x u00b9 u2075 - Arg - Lys ala ala AIB - Glu PHE ile Glu - Trp - Leu Lys ala ala Gly Gly pro Gly ala - - Be - Pro - Pro Pro - (2) - x u2074 u2070 x u00b9 u2074 represents an amino acid residue selected met and Leu NLEX u00b9 u2075 represents an amino acid residue selected from Glu and ASP, Lys x u2074 u2070 is absent or represented, r u00b9 represents nh u2082, R u00b2 represents o or nh u2082, or a Salt or solvate thereof.La presente se refiere a derivados de exendina-4 y a su uso médico, por ejemplo, en el tratamiento de trastornos del síndrome metabólico, que incluyen diabetes y obesidad, además de reducción de la ingesta excesiva de alimentos. Reivindicación 1: Un compuesto peptídico que tiene la fórmula (1): R¹-Z-R² (1) en donde Z es un resto de péptido que tiene la fórmula (2): Tyr-Aib-Glu-Gly-Thr-Phe-Thr-Ser-Asp-Leu-Ser-lle-Gln-X¹⁴-X¹⁵-Lys-Arg-Ala-Ala-Aib-Glu-Phe-lle-Glu-Trp-Leu-Lys-Ala-Gly-Gly-Pro-Ser-Ser-Gly-Ala-Pro-Pro-Pro-Ser-X⁴⁰ (2) X¹⁴ representa un residuo de aminoácido seleccionado de Met, Leu y Nle, X¹⁵ representa un residuo de aminoácido seleccionado de Glu y Asp, X⁴⁰ está ausente o representa Lys, R¹ representa NH₂, R² representa OH o NH₂, o una sal o solvato del mismo.
