MAMMALIAN ARTIFICIAL CHROMOSOME VECTOR COMPRISING HUMAN CYTOCHROME P450 GENE (CLUSTER), AND NON-HUMAN MAMMALIAN ANIMAL RETAINING THE SAME

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专利权人:

发明人:

申请号：

EP08849922.3

公开号：

EP2218786B1

申请日:

2008.10.14

申请国别(地区):

EP

年份:

2013

代理人:

摘要：

This invention relates to a mammalian artificial chromosome vector, which retains a human chromosome 7 fragment comprising human cytochrome P450 genes and is transmittable to progeny, wherein the human chromosome 7 fragment retains a region of approximately 1 Mb ± 500 Kb in size comprising at least a human CYP3A gene cluster, which region is located between chromosome markers AC004922 and AC073842, and to a non-human mammalian animal retaining the vector.

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