The present invention relates to a lipidated recombinant fusion protein, including a lipidating sequence derived from natural lipoprotein, such as the N-terminal portion of Ag473, and a tumor-associated antigen, such as inactive HPV E6E7 oncoprotein, being downstream of the lipidating sequence. The present invention further provides an immunotherapeutic composition and method, which is able to induce cytotoxic T lymphocytes responses as well as to protect mammalian against cancer diseases, for example HPV-associated tumors.本發明係關於一種脂化重組融合蛋白,其係包含一源自天然脂蛋白之脂化序列,例如Ag473的N端部分,以及一腫瘤相關抗原,例如失活型人類乳突病毒致癌蛋白E6/E7,且該腫瘤相關抗原位於該脂化序列之下游;本發明更提供一種免疫治療組合物及其方法,其能夠誘發毒殺型T淋巴細胞以保護哺乳動物免受癌症疾病(例如HPV相關腫瘤)之侵害。
