MESURE CIBLÉE DE L'ACTIVITÉ TRANSCRIPTIONNELLE LIÉE AUX RÉCEPTEURS HORMONAUX

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专利权人:

Board of Regents, The University of Texas System;Yale University

发明人:

SYMMANS, William, Fraser,SINN, Bruno,HATZIS, Christos,FU, Chunxiao,LAU, Rosanna

申请号：

EP17790517

公开号：

EP3449017A4

申请日:

2017.04.28

申请国别(地区):

EP

年份:

2020

代理人:

摘要：

Provided herein are methods of determining tumoral sensitivity to hormonal (endocrine) therapy based upon an index of estrogen receptor (ER)- and progesterone receptor (PR)-related genes, referred to as the sensitivity to endocrine therapy index (SETER/PR index), and may have additional consideration for the proportion of ER gene (ESRl) RNA transcripts that contain a mutation relative to the value of the SETER/PR index. Further provided are methods of treating breast cancer patients determined to be sensitive to an endocrine therapy by the SETER/PR index.

来源网站：

中国工程科技知识中心

来源网址：

http://www.ckcest.cn/home/