BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM; THE UNIVERSITY OF TEXAS SYSTEM;YALE UNIVERSITY;BOARD OF REGENTS
发明人:
SYMMANS, WILLIAM FRASER,SINN, BRUNO,HATZIS, CHRISTOS,FU, CHUNXIAO,LAU, ROSANNA
申请号：
CA3022377
公开号：
CA3022377A1
申请日:
2017.04.28
申请国别(地区):
CA
年份:
2017
代理人:
摘要：
Provided herein are methods of determining tumoral sensitivity to hormonal (endocrine) therapy based upon an index of estrogen receptor (ER)- and progesterone receptor (PR)-related genes, referred to as the sensitivity to endocrine therapy index (SETER/PR index), and may have additional consideration for the proportion of ER gene (ESRl) RNA transcripts that contain a mutation relative to the value of the SETER/PR index. Further provided are methods of treating breast cancer patients determined to be sensitive to an endocrine therapy by the SETER/PR index.
