Anne BERTOLOTTI,Indrajit DAS,Agnieszka KRZYZOSIAK,Adrien ROUSSEAU,Kim SCHNEDIDER,Anna Gudny SICURDARDOTTIR
申请号：
US15564834
公开号：
US20180111896A1
申请日:
2016.04.08
申请国别(地区):
US
年份:
2018
代理人:
摘要：
The present invention relates to inhibitors of PPP1 R15A and PPP1 R15B and their use in therapy, particularly in the treatment of a disease state alleviated by the inhibition of PPP1 R15A and PPP1 R15B, for example a disorder associated with accumulation of misfolded proteins or proteostatsis disorder. Compounds of the invention include compounds having the formula IA or a pharmaceutically acceptable salt thereof, wherein R1a, R3a, R5a, Xa and Ya are as defined herein.
