Compounds of formula 1, as well as their pharmacologically compatible salts for use in the treatment of a disease chosen from the group of idiopathic pulmonary fibrosis, cystic fibrosis, deficiency in anti-trypsin alpha-1 and rheumatoid arthritis, ** Formula ** in which X is SO or SO2； R1 is H, C1-6 alkyl, R2 is H or a radical selected from the group consisting of C1-10 alkyl and C2-6 alkenyl, which may eventually be substituted with one or more radicals selected from halogen and C1-3 fluoroalkyl or which it may eventually be substituted with one or more radicals selected from the group consisting of OR2.1, COOR2.1, CONR2.2R2.3, SR2.1, SO-R2.1, SO2-R2.1, aryl C6-10, -Het, Hetaryl, a monocyclic or bicyclic C3-10 cycloalkyl, CH2-NR2.2R2.3 and NR2.2R2.3, which, again, may eventually be substituted with one or more radicals selected from the group consisting of OH, halogen , OR2.1, oxo, CF3, CHF2, CH2F, C1-6 alkyl, C1-6 alkanol, C6-10 aryl, COOR2.1, CH2-NR2.2R2.3 and NR2.2R2.3, where Het is a heterocycle of one to eleven members, mono- or bi-cyclic, saturated or partially saturated, optionally condensed or bridged, containing 1, 2, 3 or 4 heteroatoms chosen, independently from each other, of the group consists N, S or O, and where Hetaryl is a five to ten membered heteroaryl, mono- or bi-cyclic, optionally condensed, containing 25, 1, 2, 3 or 4 heteroatoms selected, independently from each other, of the group consisting of N, S or O, and wherein cycloalkyl may be saturated or partially saturated, wherein R2.1 is H or a radical selected from the group consisting of C1-6- 30 alkyl, C1-6 alkanol, C1- haloalkyl 3, C3-10 mono- or bi-cyclic cycloalkyl, C6-10 aryl-C1-6 alkylene, C1-6 heteroaryl-alkylene, C1-6 Het-alkylene, C3-10 cycloalkyl-C1-6 alkylene, a C6 aryl -10 mono- or bi-cyclic, heteroaryl and a -Het, which may eventually be substituted by one of several radicals selected from the group consisting of OH, O- (C1-3 alkyl), halogen, C1-6 alkyl and C6 aryl- 10, 35 wherein
