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PIPERIDINO-DIHIDROTIENOPIRIMIDINAS substituted
专利权人:
BOEHRINGER INGELHEIM INTERNATIONAL GMBH
发明人:
POUZET, PASCALE,ANDERSKEWITZ, RALF,DOLLINGER, HORST,FIEGEN, DENNIS,FOX, THOMAS,GOEGGEL, ROLF,HOENKE, CHRISTOPH,MARTYRES, DOMNIC,NICKOLAUS, PETER,KLINDER, KLAUS
申请号:
ES08839793
公开号:
ES2381452T3
申请日:
2008.10.16
申请国别(地区):
ES
年份:
2012
代理人:
摘要:
Compounds of formula 1, R3 in which X is SO or SO2; R1 is H, C1-6 alkyl, R2 is H or a radical selected from the group consisting of C1-10 alkyl and C2-6 alkenyl, which may eventually be substituted with one or more radicals selected from halogen and C1-3 fluoroalkyl or which it may eventually be substituted with one or more radicals selected from the group consisting of OROR2.1 SR2.1 SO2-R2.1, COOR2.1, CONR2.2R2.3,, SO-R2.1,, C6-10 aryl, -Het, Hetaryl, a monocyclic or bicyclic C3-10 cycloalkyl, CH2-NR2.2R2.3 and NR2.2R2.3, which, again, may eventually be substituted with one or more radicals selected from the group consisting of OH, halogen , OR2.1, oxo, CF3, CHF2, CH2F, C1-6 alkyl, C1-6 alkanol, C6-10 aryl, COOR2.1, CH2-NR2.2R2.3 and NR2.2R2.3, where Het is a heterocycle of one to eleven members, mono- or bi-cyclic, saturated or partially saturated, optionally condensed or possibly bridged, containing 1, 2, 3 or 4 heteroatoms chosen, independently of each other, from the group consisting of N, S or O, and wherein Hetaryl is a five to ten membered heteroaryl, mono- or bi-cyclic, optionally condensed, containing 1, 2, 3 or 4 heteroatoms selected, independently of one another, from the group consisting of N, S or O, and wherein cycloalkyl may be saturated or partially saturated, wherein R2.1 is H or a radical selected from the group consisting of C1-6- alkyl, C1-6 alkanol, C1-3 haloalkyl, C3-10 mono- or bi-cyclic cycloalkyl, C6-10 aryl-C1-6 alkylene, C1-6 heteroaryl-alkylene, C1-6 Het-alkylene, C3-10 cycloalkyl-C1-6 alkylene, a C6-10 aryl mono- or bi-cyclic, heteroaryl and a -Het, which may eventually be substituted with one several radicals selected from the group consisting of OH, O- (C1-3 alkyl), halogen, C1-6 alkyl and C6-10 aryl, and R2.3 wherein R2.2 are, independently of each other, H or a radical that is selected from the group consisting of C1-6 alkyl, mono-or bicyclic C3-10 cycloalkyl, C6-10-a aryl C1-6 alkylene, C1-6 heteroarylene, mono- or bicyclic C6-10 a
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