The present invention relates to a kind of novel antibodies to be specifically bound to TSPAN8 (tetratransmembrane superfamily 8) and application thereof. More specifically,The present invention relates to antibody specificities to be integrated to LEL(Big extracellular ring) TSPAN8,A kind of composition preparing the antibody,It include antibody for inhibit cancer and/or cancer metastasis,For inhibiting cancer and/or cancer metastasis or by administration of antibodies composition,It include antibody for preventing and treating cancer and/or cancer metastasis,For treating or preventing cancer and/or cancer metastasis or the composition by applying the antibody,The composition includes antibody for cancer diagnosis and/or cancer metastasis,For diagnosing the kit of cancer,Method comprising the composition,A kind of cancer diagnosis composition,The composition is used to inhibit cancer and/or cancer metastasis includes the kit that material TSPAN8 inhibits expression,It includes the composition for cancer and/or cancer metastasis,For inhibiting cancer and/or cancer metastasis or cancer therapeutic composition,And cancers and/or cancer metastasis of the TSPAN8 in the LEL as the antibody inhibition of epitope.
