LEE, Sukmook,KIM, Taek-Keun,PARK, Chang Sik,JEOUNG, Mee Hyun,KI, Min Kyoung,LEE, Woo Ran,GO, Nam Kyung,CHOI, Jong Rip
申请号：
KRKR2015/001905
公开号：
WO2015/130115A1
申请日:
2015.02.27
申请国别(地区):
WO
年份:
2015
代理人:
摘要：
The present invention relates to a novel antibody specifically binding to the TSPAN8 (tetraspanin 8) and uses thereof. More particularly, the present invention relates to an antibody specifically binding to the LEL (large extracellular loop) of TSPAN8, a method for preparing the antibody, a composition for the suppression of cancer and/or cancer metastasis comprising the antibody, a method for suppressing cancer and/or cancer metastasis by administering the antibody or the composition, a composition for preventing or treating cancer and/or cancer metastasis comprising the antibody, a method for preventing or treating cancer and/or cancer metastasis by administering the antibody or the composition, a composition for diagnosing cancer and/or cancer metastasis comprising the antibody, a kit for diagnosing cancer comprising the composition, a method for diagnosing cancer using the composition, a composition for the suppression of cancer and/or cancer metastasis comprising a material for inhibiting expression of TSPAN8, a kit for cancer and/or cancer metastasis comprising the composition, a method for suppressing cancer and/or cancer metastasis or treating cancer using the composition, and the use of the LEL of TSPAN8 as an epitope for an antibody suppressive of cancer and/or cancer metastasis.La présente invention concerne un nouvel anticorps se liant spécifiquement à la TSPAN8 (tétraspanine 8) et ses utilisations. Plus particulièrement, la présente invention concerne un anticorps se liant particulièrement à la LEL (grande boucle extracellulaire) de la TSPAN8, un procédé de préparation de lanticorps, une composition de suppression du cancer et/ou des métastases cancéreuses comprenant lanticorps, un procédé de suppression du cancer et/ou des métastases cancéreuses par ladministration de lanticorps ou de la composition, une composition de prévention ou de traitement du cancer et/ou des métastases cancéreuses comprenant lanticorps, un procédé de prévention ou de traitement
