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Inhibiting interaction between the HIF-1ALPHA and p300/CBP with hydrogen bond surrogate-based helices
专利权人:
Bogdan Olenyuk;Ross N. Chapman;Paramjit S. Arora;Laura Henchey;Katherine M. Block
发明人:
Paramjit S. Arora,Bogdan Olenyuk,Ross N. Chapman,Laura Henchey,Katherine M. Block
申请号:
US13119108
公开号:
US09399666B2
申请日:
2009.09.18
申请国别(地区):
US
年份:
2016
代理人:
摘要:
The present invention relates to peptides having one or more stable, internally constrained α-helices, and that include a sequence that mimics at least a portion of the C-terminal transactivation domain of HIF-1α. Also disclosed are pharmaceutical compositions containing these peptides and methods of using these peptides, for example to reduce gene transcription, treat or prevent disorders mediated by interaction of HIF-1α with CREB-binding protein and/or p300, reduce or prevent angiogenesis in a tissue, induce apoptosis, decrease cell survival and/or proliferation, and identify potential ligands of CREB-binding protein and/or p300.
来源网站:
中国工程科技知识中心
来源网址:
http://www.ckcest.cn/home/

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