Bogdan Olenyuk;Ross N. Chapman;Paramjit S. Arora;Laura Henchey;Katherine M. Block
发明人:
Paramjit S. Arora,Bogdan Olenyuk,Ross N. Chapman,Laura Henchey,Katherine M. Block
申请号：
US13119108
公开号：
US09399666B2
申请日:
2009.09.18
申请国别(地区):
US
年份:
2016
代理人:
摘要：
The present invention relates to peptides having one or more stable, internally constrained α-helices, and that include a sequence that mimics at least a portion of the C-terminal transactivation domain of HIF-1α. Also disclosed are pharmaceutical compositions containing these peptides and methods of using these peptides, for example to reduce gene transcription, treat or prevent disorders mediated by interaction of HIF-1α with CREB-binding protein and/or p300, reduce or prevent angiogenesis in a tissue, induce apoptosis, decrease cell survival and/or proliferation, and identify potential ligands of CREB-binding protein and/or p300.
