Arora, Paramjit,Olenyuk, Bogdan,Chapman, Ross N.,Henchey, Laura,Block, Katherine M.
申请号：
AU2015202742
公开号：
AU2015202742A1
申请日:
2015.05.20
申请国别(地区):
AU
年份:
2015
代理人:
摘要：
#$%^&*AU2015202742A120150611.pdf#####ABSTRACT The present invention relates to peptides having one or more stable, internally constrained ahelices, and that include a sequence that mimics at least a portion of the C-terminal transactivation domain of HIF-la. Also disclosed are pharmaceutical compositions containing these peptides and methods of using these peptides, for example to reduce gene transcription, treat or prevent disorders mediated by interaction of HIF-la with CREB-binding protein and/or p300, reduce or prevent angiogenesis in a tissue, induce apoptosis, decrease cell survival and/or proliferation, and identify potential ligands of CREB -binding protein and/or p300.
