ELMER, Eskil,HANSSON, Magnus Joakim,EHINGER, Karl Henrik Johannes,MOSS, Steven
申请号：
ES15714820
公开号：
ES2683860T3
申请日:
2015.04.08
申请国别(地区):
ES
年份:
2018
代理人:
摘要：
Compound according to the invention that is given by formula (I) ** Formula ** or a pharmaceutically acceptable salt thereof, in which the discontinuous bond between A and B indicates an optional bond to form a closed ring structure, and in where Z is selected from -CH2-CH2- or>； CH (CH3), A is selected from -SR, -OR and NHR, and R is ** Formula ** or B is selected from -O-R ', - NHR ", -SR" 'or -OH； and R 'is selected from formulas (II) to (IX) below: R', R "and R" 'are independently different or identical and are selected from formulas (IV25 VIII) below: ** Formula ** or R1 and R3 are independently different or identical and are selected from H, Me, Et, propyl, ipropyl, butyl, iso-butyl, t-butyl, O-acyl, O-alkyl, N-acyl, N-alkyl, X -acrylic, CH2X-alkyl, CH2Xacrylic, F, CH2COOH, CH2CO2-alkyl, X is selected from O, NH, NR6, S, R2 is selected from Me, Et, propyl, i-propyl, butyl, iso-butyl, t -butyl, C (O) CH3, C (O) CH2C (O) CH3, C (O) CH2CH (OH) CH3, p is an integer and is 1 or 2 R6 is selected from H, Me, Et, propyl , i-propyl, butyl, iso-butyl, t-butyl, acetyl, acyl, propionyl, benzoyl, or formula (II), or formula (VIII) X5 is selected from -H, Me, Et, propyl, i -propyl, butyl, iso-butyl, t-butyl, -COOH, -C (>； = O) XR6, CONR1R3 or is the formula ** Formula ** X7 is selected from R1, -NR1R3, R9 is selected from H, Me, Et or O2CCH2CH 2COXR8 R10 is selected from O-acyl, NH-alkyl, NH-acyl or O2CCH2CH2COX6R8 X6 is selected from O, NR8, NR6R8, in which R6 and R8 are independently different or identical and are selected from H, alkyl, Me, Et , propyl, i-propyl, butyl, iso-butyl, t-butyl, acetyl, acyl, propionyl, benzoyl, or formula (II), or formula (VIII), R11 and R12 are independently different or identical and are selected of H, Me, Et, propyl, ipropyl, butyl, iso-butyl, t-butyl, acetyl, propionyl, benzoyl, -CH2X-alkyl, -CH2X-acyl, wherein X is O, NR6 or S, Rc and Rd are independently different or identical and are selected from CH2X-alkyl, CH2Xacrylic, in which
