AMARI, Gabriele,ARMANI, Elisabetta,GHIDINI, Eleonora,BAKER-GLENN, Charles,VAN DE PÖEL, Hervé,WHITTAKER, Ben
申请号：
ES14814786
公开号：
ES2655047T3
申请日:
2014.12.04
申请国别(地区):
ES
年份:
2018
代理人:
摘要：
A compound of general formula (I) ** Formula ** wherein each R1 is hydrogen or is independently selected from the group consisting of: halogen, (C1-C4) alkyl, (C1-C4) alkoxy, (C1-C4 ) haloalkyl, hydroxy, -SO2NR6R7, -CN, -NR8SO2R9, -NR6R7, -CONR6R7 and -NR8COR9 and wherein said (C1-C4) alkyl is optionally substituted with one or more groups selected from (C3-C7) cycloalkyl, hydroxy and -NR6R7 and wherein said (C1-C4) alkoxy is optionally substituted with one or more halogens or (C3-C7) cycloalkyl groups wherein, R6 is hydrogen or (C1-C6) alkyl； R7 is hydrogen or (C1-C6) alkyl； R8 is hydrogen or (C1-C6) alkyl； R9 is hydrogen or (C1-C6) alkyl； n is an integer that varies from 1 to 3； each R2 is hydrogen or is selected from the group consisting of: halogen, (C1-C4) alkyl, (C1-C4) alkoxy, (C1-C4) haloalkyl, hydroxy, -SO2NR10R11, -CN and -NR12SO2R13 and wherein said (C1-C4) alkyl and said (C1-C4) alkoxy are optionally substituted by one or more (C3-C7) cycloalkyl groups wherein R10 is hydrogen or (C1-C6) alkyl； R11 is hydrogen or (C1-C6) alkyl； R12 is hydrogen or (C1-C6) alkyl； R13 is hydrogen or (C1-C6) alkyl； m is an integer that varies from 1 to 3； R3 and R4 are different or equal and are independently selected from the group consisting of: - H； - (C3-C7) cycloalkylcarbonyl； - (C1-C6) alkyl, optionally substituted by one or more substituents selected from (C3-C7) cycloalkyl or (C5-C7) cycloalkenyl； - (C1-C6) haloalkyl； - (C3-C7) cycloalkyl； - (C5-C7) cycloalkenyl； - (C2-C6) alkenyl； and - (C2-C6) alkynyl； or R3 and R4, together with the interconnected atoms, form a 2,2-difluoro-1,3-dioxolane ring of formula (r) fused to the phenyl structural unit that carries -OR3 and -OR4 groups, where the asterisks indicate carbon atoms shared with said phenyl ring every R5, whenever present, is independently selected from the group consisting of: CN, NO2, CF3 and halogen atoms； k is 0 or an integer that varies from 1 to 3； L1 is selected from the list consisting of: - a link, - - (C
