BROWN, MATTHEW FRANK,CHE, YE,MARFAT, ANTHONY,MELNICK, MICHAEL JOSEPH,MONTGOMERY, JUSTIN IAN,REILLY, USA
申请号：
ES10803646
公开号：
ES2525820T3
申请日:
2010.12.06
申请国别(地区):
ES
年份:
2014
代理人:
摘要：
A compound of formula: or a pharmaceutically acceptable salt thereof, wherein: R1 is represented by C1-C3 alkyl； R2 is represented by hydrogen or C1-C3 alkyl； R3 is represented by hydrogen, halogen, C1-C3 alkyl, C1-C3 alkoxy, trifluoromethyl or trifluoromethoxy； L is absent, or is represented by a moiety selected from the group consisting of C1-C6 alkylene which may be optionally substituted in which up to a maximum of 6 hydrogen atoms are substituted by a substituent selected from the group consisting of halogen , cyano, sulfonamide, imino, iminohydroxy, -O-Ra, -SRa and -NRaRb, in which each of Ra and Rb is independently represented by hydrogen or C1-C6 alkyl； C2-C6 alkenylene； C2-C6 alkynylene； - (CH2) p-O- (CH2) n, - (CH2) p-O- (CH2) z-O- (CH2) n-； n is represented by an integer between 0 and 4； p is represented by an integer between 0 and 4； q is represented by an integer between 0 and 6； z is represented by an integer between 1 and 4； D is represented by a substituent selected from the group consisting of: i) saturated or partially unsaturated (C3-C10) cycloalkyl, wherein said cycloalkyl is a bicyclic, bicyclic bridged or tricyclic alkyl radical, in which each cyclic moiety it contains from 3 to 10 carbon atoms, and in which said cycloalkyl group may be optionally substituted, in which up to a maximum of 4 hydrogen atoms are substituted by a substituent or substituents selected (s) from the group consisting of halogen , cyano, nitro, hydroxy, (C1-C6) alkyl, (C1-C6) alkoxy, trifluoromethyl, trifluoromethoxy, phosphate, oxo, -SO2NR4R5, - (CH2) m-NR5-C (O) -R4, - (CH2 ) mC (O) -N-R4R5, -C (O) R4, -C (O) -O-R4, -SR4, -SO2R4 and -NR4R5, substituents that may be the same or different； ii) aryl (C6-C10), optionally substituted with a maximum of 4 substituents other than hydrogen, in which each substituent is independently selected from the group consisting of halogen, cyano, nitro, hydroxy, (C1-C6) alkyl, (C1-C6) alkoxy, trifluoromethyl, trifluoromethoxy, phosphate, -
