VIDAL JUAN BERNAT,VIDAL GISPERT LAURA,BACH TAA JORDI,GONZALEZ RODRIGUEZ JACOB
申请号：
ARP110104376
公开号：
AR087328A1
申请日:
2011.11.24
申请国别(地区):
AR
年份:
2014
代理人:
摘要：
The compounds are useful in therapy of Immune and inflammatory diseases.Claim 1: a compound of formula (1) or a pharmaceutically acceptable Salt or solvate or stereoisomer or N - Oxide, or taut u00f3mero deuterated or derivative thereof, where M is an integer of 0 OR 1 to 3； each of X and y separately represents a nitrogen Atom or a group Po - CR7,Where at least one of X and y represents a Group - CR7； one of G1 and G2 represents a nitrogen Atom and the other represents a carbon Atom； each of R1 and R2 independently represents a hydrogen Atom, an atom of the Hydroxy Group, halogen, a cyano Group, an alkyl group Linear or branched C1 - 6, a group haloalquilo c1-4, a group hidroxialquilo c1-4,A cycloalkyl Group C3 - 10 - 10 cicloalquenilo C3, a Group, an aryl Group monocyclic or polycyclic heteroaryl [14, a group of 5 to 14 Member contains at least a heteroatom selected from o, s and N Group, a Heterocyclic 5 to 14 Member contains at least one hetero Atom. Ccionado o, s and N, where groups haloalquilo, alkyl, cycloalkyl, hidroxialquilo,Cicloalquenilo, aryl, Heterocyclic and heteroaryl, are unsubstituted or substituted with one or more substituents selected from a Halogen Atom, a cyano Group, a linear or branched alkyl group C1 - 6, a group haloalquilo c1-4, a group hidroxialquilo c1-4, a Group alquilsulfonilo 4 C1 - C3 - 7, a cycloalkyl Group, a phenyl Group, a group piridilo,A group or a Group pirimidinilo piperidilo； or each of R1 and R2 independently represent a Group - (CH2) 0 - 2or9, a Group - or - (CH2) 1 - 2or9, or a Group - nr8r9； R3 represents a hydrogen Atom, an atom of halogen, a cyano Group, an alkyl group linear or branched C1 Group 6, a Halo C1-4 alkyl group, a hidroxialquilo C1 - C3 - 4, a cycloalkyl Group, a group cicloalquenilo C3 - 10A group of monocyclic or polycyclic aryl heteroaryl [14, a group of 5 to 14 Member contains at least a heteroatom selected from o, s and N Group, a Heterocyclic 5 to 14 Member contains at least a heteroatom selected from
