612336 Disclosed are N-{ amino-alkyl} -isoquinoline-6-sulfonamide derivatives as represented by the general formula (I), a salt thereof, or a solvate of the derivative or the salt, wherein R3 and R4 each independently represent a hydrogen atom, an alkyl group, a hydroxyalkyl group, a dialkylaminoalkyl group, or an aminoalkanoyl group R5 represents a hydrogen atom, an optionally substituted alkyl group, an optionally substituted alkenyl group, an optionally substituted alkynyl group, an optionally substituted cycloalkyl group, or an optionally substituted alkanoyl group, or R4 and R5 may form a saturated heterocyclic ring together with the adjacent nitrogen atom A represents a linear or branched alkylene group having 2 to 6 carbon atoms and optionally having at least one substituent selected from a carboxyl group, a halogen atom, a cyano group, an oxo group, an alkenyl group, an alkynyl group, an alkoxy group, a hydroxyl group, an alkyloxycarbonyl group, an aminoalkyl group, an aryl group, a heteroaryl group, an optionally substituted aralkyl group, and an optionally substituted heteroarylalkyl group. Representative compounds include (R)-N-{ 1-(benzylamino)propan-2-yl} isoquinoline-6-sulfonamide dihydrochloride, (R)-N-{ 1-(ethylamino)propan-2-l} isoquinoline-6-sulfonamide dihydrochloride, (S)-N-{ 1-(butylamino)propan-2-yl} isoquinoline-6-sulfonamide dihydrochloride, (R)-N-{ 1-(isobutylamino)propan-2-yl} isoquinoline-6-sulfonamide dihydrochloride, (R)-N-{ 1-(2-fluorophenethylamino)propan-2-yl} isoquinoline-6-sulfonamide dihydrochloride, (R)-N-[1-{ 2-(1H-1,2,4-triazol-1-yl)ethylamino} propan-2-yl]isoquinoline-6-sulfonamide hydrochloride, (R)-1-amino-N-{ 1-(phenethylamino)propan-2-yl} isoquinoline-6-sulfonamide hydrochloride, (R)-N-{ 1-(phenethylamino)propan-2-yl} -1-hydroxyisoquinoline-6-sulfonamide hydrochloride and (R)-N-{ 1-(phenethylamino)propan-2-yl} -4-(thiophen-3-yl)isoquinoline-6-sulfonamide dihydrochloride. Further disclosed is a pharmaceutical composition con
