БИШОФФ Александр (US),СУНДАРЕСАН Кумар (IN),КОТЕСУВАРА РАО П.Бала (IN),АЙНАН Бхаратсираджа (IN),АЙЯАМПЕРУМАЛ Харихарасубраманиан (IN),А Р Гириш (IN),ТАТИПАРТСИ Сринивас (IN),ПРАБХУ Ганеш (IN),СУБРАМАН
申请号：
RU2010142937/04
公开号：
RU2010142937A
申请日:
2009.03.20
申请国别(地区):
RU
年份:
2012
代理人:
摘要：
1. A compound of formula: Where n is 1 or 2 ! R1 is aryl or heteroaryl ! R2 is aryl or heteroaryl ! each of R3 and R4 is hydrogen ! R5 represents hydrogen ! m and n are independently 1 or 2,! X represents -O-, -NR6-, -S-, -S (O) - or -S (O) 2-, wherein R6 is hydrogen or alkyl ! wherein the aryl, heteroaryl or heterocyclic group, if present, may be optionally substituted with one or more halogen, hydroxy, cyano, nitro, amino, dialkylamino, arylamino, amido, carboxyl, alkyl, halogenated alkyl, cycloalkyl, heteroaryl, heterocycle, acyl, alkoxy or alkylsulfonyl, and combinations thereof ! and pharmaceutically acceptable salts, solvates, hydrates, solvates of pharmaceutically acceptable salts or its enantiomer or diastereomer,! provided that the compound is not! 4 - [[(2R) -2,3-dihydro-2-methyl-6-nitroimidazo [2,1-b] oxazol-2-yl] methoxy] -N- [2-oxo-2- [4- [ 4- (trifluoromethoxy) phenoxy] -1-piperidinyl] ethyl] benzamide,! N- [2- [4 - [[4-amino-5- (2,6-difluorobenzoyl) -2-thiazolyl] amino] -1-piperidinyl] -2-oxoethyl] -N-methyl-benzamide,! 4-amino-N- [2- [4 - [[4-amino-5- (2,6-difluorobenzoyl) -2-thiazolyl] amino] -1-piperidinyl] -2-oxoethyl] -benzamide,! or their pharmaceutically acceptable salts. ! 2. A compound according to claim 1, wherein R1 represents aryl substituted by one or more aryl groups. ! 3. A compound according to claim 1, wherein R1 is heteroaryl and is substituted by one or more aryl or heteroaryl groups. ! 4. A compound according to claim 1, wherein R1 represents a pyrazole, triazole or isoxazole. ! 5. A compound according to claim 1, wherein R2 is aryl. ! 6. A compound according to claim 1, wherein the compound is a1. Соединение формулы:где n равно 1 или 2R1 представляет собой арил или гетероарилR2 представляет собой арил или гетероарилкаждый из R3 и R4 представляет собой водородR5 представляет собой водородm и n независимо равны 1 или 2,Х представляет собой -O-, -NR6-, -S-, -S(O)- или -S(O)2-, где R6 представляет собой водород или алкилгде арильная,
