Elizabeth Mary Beck,Michael Aaron Brodney,Matthew Frank Brown,Christopher Ryan Butler,Adam Matthew Gilbert,Erik Alphie Lachapelle,Laura Ann McAllister,Daniel Paul Uccello,Lei Zhang
申请号：
US16625202
公开号：
US20200262833A1
申请日:
2018.06.14
申请国别(地区):
US
年份:
2020
代理人:
摘要：
The present invention provides, in part, compounds of Formula I, or an N-oxide thereof, or a pharmaceutically acceptable salt of the compound or the N-oxide, wherein: (R1)a, (R2)b, (R3)c, L, A, and E are as described herein； processes for the preparation of； intermediates used in the preparation of； and compositions containing such compounds, N-oxides, or salts, and their uses for treating M4-mediated (or M4-associated) disorders including, e.g., Alzheimer's Disease, schizophrenia (e.g., its cognitive and negative symptoms), pain, addiction, and a sleep disorder.
