ZHANG, LEI,BUTLER, CHRISTOPHER RYAN,BECK, ELIZABETH MARY,BRODNEY, MICHAEL AARON,BROWN, MATTHEW FRANK,MCALLISTER, LAURA ANN,LACHAPELLE, ERIK ALPHIE,GILBERT, ADAM MATTHEW
申请号：
CA2972070
公开号：
CA2972070A1
申请日:
2017.06.28
申请国别(地区):
CA
年份:
2018
代理人:
摘要：
The present invention provides, in part, compounds of Formula l:(see formula I)or an N-oxide thereof, or a pharmaceutically acceptable salt of the compoundor the N-oxide,wherein: R1, R2, L, A, and E are as described herein； processes for thepreparation of；intermediates used in the preparation of； and compositions containing suchcompounds,N-oxides, or salts, and their uses as a positive allosteric modulator (PAM) ofthe M4 muscarinicacetylcholine receptor.
