Ermanno Gherardi;Daniel Lietha;Dimitry Yurievich Chirgadze;Thomas Leon Blundell
发明人:
Ermanno Gherardi,Daniel Lietha,Thomas Leon Blundell,Dimitry Yurievich Chirgadze
申请号：
US12858189
公开号：
US08232258B2
申请日:
2010.08.17
申请国别(地区):
US
年份:
2012
代理人:
摘要：
The present invention relates to variants of the NK1 fragment of the polypeptide growth factor HGF/SF which act as agonists of the MET receptor and their use. The agonists comprise at least one substitution at positions equivalent to 132, 134, 170 and 181 of full length HGF/SF and these substitutions provide a variant which shows scatter factor activity and induces DNA synthesis. In vivo the variants provide protection from liver damage in a model of acute liver failure.
