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A NOVEL CYANOPYRIMIDINE DERIVATIVE
专利权人:
OTSUKA PHARMACEUTICAL CO.; LTD.
发明人:
SATO, NORIFUMI,YUKI, YOHEI,SHINOHARA, HISASHI,TAKEJI, YASUHIRO,ITO, KUNI,MICHIKAMI, DAISAKU,HINO, KEISUKE,YAMAZAKI, HIROYUKI
申请号:
NZ59397510
公开号:
NZ593975A
申请日:
2010.02.02
申请国别(地区):
NZ
年份:
2012
代理人:
摘要:
Disclosed herein is a cyanopyrimidine compound of formula (I), wherein R is selected from hydrogen, hydroxy (lower alkyl) group, halogenated (lower alkyl) group or (lower alkoxy)carbonyl-(lower alkyl) group or a salt thereof, processes for their preparation, compositions comprising said compounds and uses thereof. Said compounds are useful as adenosine A2a receptor agonists and are therefore useful in treating or preventing eye disease such as glaucoma. Specific examples of preferred compounds include: · N-(4-(6-amino-5-cyano-2-((6-(3-oxo-3-(4-(piperidin-4-ylmethyl) piperazin-1-yl) propyl) pyridine-2-yl) methylthio)-pyrimidine-4-yl) phenyl) acetamide, · N-(4-(6-amino-5-cyano-2-((6-(3-(4-((1-(2-hydroxyethyl)-piperidine-4-yl)methyl)piperazin-1-yl)-3-oxopropyl)-pyridine-2-yl)methylthio)pyrimidine-4-yl)phenyl)acetamide, · N-(4-(6-amino-5-cyano-2-((6-(3-(4-((1-(3-hydroxy-propyl)piperidine-4-yl)methyl)piperazin-1-yl)-3-oxopropyl)-pyridine-2-yl)methylthio)pyrimidine-4-yl)phenyl)acetamide, · N-(4-(6-amino-5-cyano-2-((6-(3-(4-((I-(2-fluoroethyl)piperidine-4-yl)methyl)piperazin-1-yl)-3-oxopropyl)pyridine-2-yl)methylthio)pyrimidine-4-yl)phenyl)acetamide, and · N-(4-(6-amino-5-cyano-2-( (6-(3-(4-( (1-(2-methoxy-carbonylethyl)piperidine-4-yl)methyl)piperazin-l-yl)-3-oxopropyl) pyridine-2-yl)methylthio) pyrimidine-4-yl)phe nyl)-acetamide.
来源网站:
中国工程科技知识中心
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