Compounds useful in the treatment of CNS diseases, Metabolic Disorders (diabetes), Lung, Heart, Eye Disorders (Diabetic Retinopathy, glaucoma), inflammation.Claim 1: a compound of the formula (1), which is haloalquilo: r u00b9, halofenilo, alcoxifenilo, alkyl - oxadiazolilo 1,2,5, haloalquilfenilo, alquilsulfonilfenilo, Halo - pyridinyl or alquiltetrazolilo； R u00b2 is alquenilo, cycloalkyl, Isopropyl, piperidinilo, alquilamino, azetidinilo, PI Rrolidinilo, cicloalquilamino, alquiloxetanilamino, morfolinilo (cicloalquil (alkyl) amino)Haloalquiloxi, alkoxy, cicloalquilalcoxi, cicloalquiloxi, oxetaniloxi, alquiloxetanilalquiloxi, alquiniloxi alkoxy -, alkoxy, hidroxialquiloxi, alquilsulfanilo, haloalquil - sulfanilo, alquilsulfonilo, hidroxialquilsulfanilo, hydroxy alquilsulfonilo or alcoxialquilsulfonilo r u00b3 are chosen； and r u2074 IND Ependencia between Hydrogen, halogen, alkyl and hydroxyl alquilcarbonilamino,Under the condition that r u00b3 and r u2074 Hydrogen are not both at the same time； and N is 1 or 2； or a pharmaceutically acceptable Salt or Ester thereof； provided that excludes the (S) - 1 - [3 - (4 - methoxy benzyl) - 5 - (2,2,2 - trifluoro - ethoxy) - 3 - [1,2,3] triazolo [4,5-d] pyrimidine 7 - yl] - RIP Rolidin - 3 - ol.Mevcut buluş, aşağıda gösterilen bir formül (I) bileşiği olup, burada R1 ila R4 tarifnamede ve istemlerde tanımlandığı şekildedir. Formül (I) bileşiği bir ilaç olarak kullanılabilir.
