The present invention provides a bone cement formula having a powder component and a setting liquid component, wherein the powder component includes a calcium sulfate source and a calcium phosphate source with a weight ratio of the calcium sulfate source less than 65%, based on the total weight of the calcium sulfate source and the calcium phosphate source, and the setting liquid component comprises ammonium ion (NH4+) in a concentration of about 0.5 M to 4 M, wherein the calcium phosphate source includes tetracalcium phosphate (TTCP) and dicalcium phosphate in a molar ratio of TTCP to dicalcium phosphate of about 0.5 to about 2.5, and the calcium sulfate source is calcium sulfate hemihydrate (CSH), calcium sulfate dehydrate (CSD), or anhydrous calcium sulfate.本發明提供了一種具有粉末組份和固化液體組份的骨水泥配方,其中,所述粉末組份含有硫酸鈣源和磷酸鈣源,以硫酸鈣源和磷酸鈣源的總重量為基準,所述硫酸鈣源的重量比小於65%,並且所述固化液體組份含有濃度為約0.5 M至4 M的銨離子(NH4+),其中,所述磷酸鈣源包括磷酸四鈣(TTCP)和磷酸二鈣,其中TTCP與磷酸二鈣的摩爾比為約0.5至約2.5,並且所述硫酸鈣源為半水合硫酸鈣(CSH)、脫水硫酸鈣(CSD)或無水硫酸鈣。
