PROCEDIMIENTO PARA LA PREPARACION DE LOS METABOLITOS DE (4S)- Y (4R)-4-(4-CIANO-2-METOXIFENIL)-5-ETOXI-2,8-DIMETIL-1,4-DIHIDRO-1, 6-NAFTIRIDINA-3-CARBOXAMIDA Y EL USO DE LOS MISMOS.
The present invention relates to a novel method for the preparation of (4R)-4-(4-cyano-2-methoxyphenyl)-5-ethoxy-2,8-dimethyl-1,4-dihy dro-1,6-naphthyridine-3-carboxamide of the formula 4R (I) and the metabolites of (4S)- and (4R)-4-(4-cyano-2-methoxyphenyl)-5-ethoxy-2,8-dimethyl-1,4-dihy dro-1,6-naphthyridine-3-carboxamide of the formula (I), of the formulae M1a (S), M1b (R), M2a (S), M2b (R), M3a (S) and M3b (R) and the use thereof.La presente invención se refiere a un nuevo procedimiento de preparación de (4R)-4-(4-ciano-2-metoxifenil)-5-etoxi-2,8-dimetil- 1,4-dihidro-1, 6-naftiridina-3-carboxamida de la fórmula 4R (I) y los metabolitos de (4S)- y (4R)-4-(4-ciano-2-metoxifenil)-5-etoxi- 2,8-dimetil-1,4-dihidro-1,6-naftiridina-3-carboxamida de la fórmula (I), las fórmulas M1a (S), M1b (R), M2a (S), M2b (R), M3a (S) y M3b (R) y uso de los mismos.
