The present invention provides a compound of Formula (I): wherein R 1 , R 2 , R 3 and R 4 are each independently selected from a hydrogen atom, an optionally substituted C 1 -C 6 alkyl group, an optionally substituted C 7 -C 14 aralkyl group and -C(=O)Rx； Rx represents an optionally substituted C 1 -C 6 alkyl group, an optionally substituted aryl group, an optionally substituted heteroaryl group, an optionally substituted C 1 -C 6 alkoxy group or -NReRf； Ar 1 represents an optionally substituted aromatic carbocyclic ring or an optionally mono-substituted aromatic heterocyclic ring； Q represents -(CH 2 ) m -(L) p - or -(L)p-(CH 2 ) m -； m represents an integer selected from 0 to 2, n represents an integer selected from 1 and 2, and p represents an integer selected from 0 and 1； L represents -O-, -S- or -NR 5 -； and A represents an optionally substituted aryl group or an optionally substituted heteroaryl group, a prodrug thereof and a pharmaceutically acceptable salt thereof, as well as a pharmaceutical preparation or pharmaceutical composition comprising such a compound.本發明提供一種式(I)所示化合物、其前驅藥物、或彼等之藥學上可被接受的鹽，以及含該化合物之醫藥、醫藥組成物等，其該式(I)所示化合物：；【化1】；(I)；〔式中，R1、R2、R3及R4表示各獨立之選自氫原子、可被取代之C1－C6烷基、可被取代之C7－C14芳烷基、及－C(＝O)Rx；Rx表示可被取代之C1－C6烷基、可被取代之芳基、可被取代之雜芳基、可被取代之C1－C6烷氧基、或－NReRf；Ar1表示，可被取代之芳香族碳環、或可被取代之芳香族雜環；Q表示，－(CH2)m－(L)p－或－(L)p－(CH2)m－；m表示，選自0~2之整數，n表示選自1及2之整數，p表示選自0及1之整數；L表示，－O－、－S－或－NR5－，A表示，可被取代之芳基、或可被取代之雜芳基〕。
