Kristian HELIN,Faizaan MOHAMMAD,Jonas Westergaard HØJFELDT,Deo Prakash PANDEY,Simon WEISSMANN
申请号：
US15538434
公开号：
US20180271857A1
申请日:
2015.12.18
申请国别(地区):
US
年份:
2018
代理人:
摘要：
The invention relates to inhibitors of EZH2 for use in the treatment of cancers characterised by expression of mutated histone H3 having a mutation of amino acid number 27. The invention also relates to methods for predicting the efficacy of treatment of a cancer with an inhibitor of EZH2 by determining whether the cancer cells contain a gene encoding p16INK4A, wherein the presence of a gene encoding p16INK4A is indicative of efficacy of treatment of the cancer with an inhibitor of EZH2.
