Alexander Chucholowski,Alisher Khasanov,Gregory Parker,Tong Zhu
申请号：
US12968225
公开号：
US20120149653A1
申请日:
2010.12.14
申请国别(地区):
US
年份:
2012
代理人:
摘要：
In accordance with the present invention, novel multifunctional compounds have been developed which have orthogonal reactive groups thereon, thereby facilitating preparation of compounds having multiple functional properties (e.g., a targeting moiety and a biologically active moiety). Such constructs are useful for a variety of applications, e.g., for the delivery of biologically compatible materials, and release thereof in active form. Therefore, in accordance with the present invention, there are provided multifunctional linkers of defined structure, as well as various derivatives thereof bearing one or more biologically active components thereon. Also provided in accordance with the present invention are methods for the preparation of such constructs, as well as various uses thereof.
