CESATI, Richard,RADEKE, Heike,PANDEY, Suresh,PUROHIT, Ajay,ROBINSON, Simon
申请号：
ES13828042
公开号：
ES2763960T3
申请日:
2013.08.09
申请国别(地区):
ES
年份:
2020
代理人:
摘要：
Compound A of Formula (I): ** Formula ** or a pharmaceutically acceptable salt thereof, wherein: R1 is selected from the group consisting of hydrogen, optionally substituted alkyl, optionally substituted heteroalkyl, optionally substituted alkoxy, optionally substituted alkoxyalkyl , optionally substituted aryl, optionally substituted heteroaryl, and an imaging moiety； R2 is selected from the group consisting of hydrogen, optionally substituted alkyl, optionally substituted heteroalkyl, optionally substituted alkoxy, optionally substituted alkoxyalkyl, optionally substituted aryl, optionally substituted heteroaryl, halo, haloalkyl, -NO2, and an imaging moiety； R3 is selected from the group consisting of hydrogen, optionally substituted alkyl, optionally substituted heteroalkyl, optionally substituted alkoxy, optionally substituted alkoxyalkyl, optionally substituted aryl, optionally substituted heteroaryl, halo, haloalkyl, -CN, -NO2, and a forming moiety of pictures； J is selected from the group consisting of N (R7), S, O, C (= O), C (= O) O, OC (= O), C (= O) N (R7), N (R7) C (= O), CH2O and a bond； R4 and R5 are each independently selected from the group consisting of hydrogen, optionally substituted alkyl, and an imaging moiety, or optionally two of R4 and R5 are joined to form a ring； n is 0, 1, 2 or 3； W is aryl； Each R6 is independently selected from the group consisting of hydrogen, optionally substituted alkyl, optionally substituted alkenyl, optionally substituted alkynyl, optionally substituted heteroalkyl, optionally substituted alkoxy, optionally substituted aryloxy, optionally substituted heteroaryloxy, optionally substituted alkoxyalkyl, optionally substituted aryl, optionally heteroaryl substituted, halo, haloalkyl, -N (R7) 2, -NO2, -OH, -C (= O) R8, -C (= O) OR8, -OC (= O) R8, - C (= O) N (R7) 2, -N (R7) C (= O) R8, -CN, -Si (R9) 3, -B (R9 ') 3, -OR8 and an imaging moiety； m is 1, 2, 3, 4, 5, 6, or 7； each R7 is independently selected from the group
