PALIWAL, SUNIL,LIU, HUI,BUNKER, KEVIN DUANE,BOREN, BRANT CLAYTON,HUANG, PETER QUINHUA
申请号：
ARP180102185
公开号：
AR112774A1
申请日:
2018.08.01
申请国别(地区):
AR
年份:
2019
代理人:
摘要：
1. Claim 1: a formula compound (1),Or a pharmaceutically acceptable salt with a formula structure (1),wherein: R¹ is selected from the group consisting of an optionally substituted C₁₋₄ alkyl, an optionally substituted C₂₋₄ alkenyl, an optionally substituted C₂₋₄ alkynyl, an optionally substituted C₃₋₆ cycloalkyl, and a C₃₋₆ cycloalkyl (alkyl C₁₋₄) optionally substituted, wherein, when C₁₋₄ alkyl,C₂₋₄ alkenyl and C₂₋₄ alkynyl are independently substituted with one or more substituents selected from the group consisting of halogen, C₁₋₄ alkoxy,haloalkyl C₁₋₄,haloalkoxy C₁₋₄,Ciano, amino, single rent c832131；and wherein the rings of C₃₋₆ cycloalkyl and C₃₋₆ cycloalkyl (C₁₋₄ alkyl) are independently substituted with one or more substituents selected from the group consisting of halogen, C₁₋₄ alkyl,C₁₋₄ alkoxy,haloalkyl C₁₋₄,haloalkoxy C₁₋₄,a. Ciano, amino, single rent c832131；R² is an optionally substituted aryl or optionally substituted heteroaryl, wherein, when aryl or heteroaryl are substituted, aryl and heteroaryl are independently substituted with one or more substituents selected from the group consisting of unsubstituted C₁₋₄ alkyl and a compound of formula (2)；R³ is hydrogen or an unsubstituted C₁₋₄ alkyl； A¹ is CR⁶A or N； A² is CR⁶B or N； Z¹ is a single bond, -C (= O) - or an optionally substituted C₁₋₆ alkylene group, wherein one or two more methylene groups constituting the optionally substituted C₁₋₆ alkylene group are optionally independently replaced with an atom of oxygen or a carbonyl group, and wherein, when the C₁₋₆ alkylene group is substituted, one or more methylene groups are independently substituted with an unsubstituted C₁₋₆ alkyl group； Z² is N or C, and when Z² is N, then R⁴ᶜ is absent；R⁴ᵃ and R⁴ᵇ are independently selected from the group consisting of hydrogen, halogen, cyano, hydroxy, an unsubstituted C₁₋₆-alkyl, an unsubstituted hydroxy (C₁₋₆-alkyl), an unsubstituted alkoxy (C₁₋₆-alkyl), a unsubstituted C₂₋₇ acyl, a 2-C-unsubstituted -C-car
