Peng Luan;Pia Pauliina Yachi;Derrick Ryan Witcher;Ying Tang;Donmienne Doen Mun Leung
发明人:
Donmienne Doen Mun Leung,Peng Luan,Ying Tang,Derrick Ryan Witcher,Pia Pauliina Yachi
申请号：
US13055201
公开号：
US08609817B2
申请日:
2009.07.29
申请国别(地区):
US
年份:
2013
代理人:
摘要：
Monoclonal antibodies are provided that bind to the N-terminus of human hepcidin-25 and are characterized as having high affinity and selectivity for the polypeptide. The antibodies of the invention are useful for increasing serum iron levels, reticulocyte count, red blood cell count, hemoglobin, and/or hematocrit in a human and for the treatment of various disorders, such as anemia, in a human subject. The antibodies of the invention are also useful as analytical tools, such as in sandwich ELISA.
