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ISOTHIOUREA DERIVATIVES OR ISOUREA DERIVATIVES HAVING BACE1 INHIBITORY ACTIVITY
专利权人:
Yuusuke Tamura;Shinji Suzuki;Yuuji Kooriyama;Akihiro Hori;Sae Matsumoto
发明人:
Yuusuke Tamura,Shinji Suzuki,Sae Matsumoto,Akihiro Hori,Yuuji Kooriyama
申请号:
US13260103
公开号:
US20120015961A1
申请日:
2010.03.29
申请国别(地区):
US
年份:
2012
代理人:
摘要:
The present invention provides, for example, a compound of the following formula (I):wherein R1 is substituted amino and the like,R2 is halogen and the like,R3 is substituted or unsubstituted lower alkyl and the like,RA and RB are each independently hydrogen, substituted or unsubstituted lower alkyl and the like,RC and RD are each independently hydrogen, substituted or unsubstituted lower alkyl, or RC and RD together with the carbon atom to which they are attached may form a substituted or unsubstituted carbocycle, andring A is a carbocycle or a heterocycle,its pharmaceutically acceptable salt, or a solvate thereof as a therapeutic agent for diseases induced by production, secretion and/or deposition of amyloid-βproteins.
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