A condensed pyrimidine compound of formula I ** Formula ** in which: A is CH2, NR1, O or S； m is an integer of 1-3； n is 0 or an integer of 1-2； the ring containing A is a ring of five or six members such that the sum of m + n is 1 or 2； Y is selected from the group consisting of hydrogen, halogen, Rc, ORc, CN, CO2H, CON (Rc) 2, C (NRc) N (Rc) 2, CH2N (Rc) 2, SO2N (Rc) 2 and SO2Rc in which each Rc is independently selected from the group consisting of hydrogen, alkyl, fluoroalkyl, aryl, aralkyl, heterocyclylalkyl, heteroaryl and any combination thereof； Z is selected from the group consisting of halogen, unsubstituted alkyl of 1 to 6 carbons, alkyl or substituted alkenyl of 1 to 4 carbons, and substituted alkoxy of 1 to 4 carbons； wherein the substituted alkyl or alkenyl group is substituted with ORa, SRa, OC (O) Ra, C (O) Ra, C (O) ORa, OC (O) N (Ra) 2, C (O) N ( Ra) 2, N (Ra) C (O) ORa, N (Ra) C (O) R8, N (Ra) C (O) N (Ra) 2, N (Ra) C (NRa) N (Ra) 2, N (Ra) S (O) tRa, S (O) tORa, S (O) tN (Ra) 2, N (Ra) 2 or PO3 (Ra) 2 in which each Ra is independently hydrogen, alkyl, fluoroalkyl, aryl, aralkyl, heterocyclylalkyl, heteroaryl or any combination thereof； and, the substituted alkoxy group is substituted with ORb, Rb, OC (O) Rb, N (Rb) 2, C (O) Rb, C (O) ORb, OC (O) N (Rb) 2, C (O ) N (Rb) 2, N (Rb) C (O) ORb, N (Rb) C (O) Rb, N (Rb) C (O) N (Rb) 2, N (Rb) C (NRb) N (Rb) 2, N (Rb) S (O) tRb, S (O) tORb, S (O) tN (Rb) 2, N (Rb) 2 or PO3 (Rb) 2 in which each Rb is independently hydrogen , alkyl, fluoroalkyl, aryl, aralkyl, heterocyclylalkyl, heteroaryl, or any combination thereof； R1 is selected from a group consisting of hydrogen, unsubstituted alkyl of 1 to 6 carbons, substituted alkyl of 1 to 4 carbons and -C (O) Rd； wherein, the substituted alkyl is substituted with ORd, SRd, OC (O) Rd, C (O) Rd, C (O) ORd, -OC (O) N (Rd) 2, C (O) N (Rd ) 2, N (Rd) C (O) ORd, N (Rd) C (O) Rd, N (Rd) C (O) N (Rd) 2, N (Rd) C (NRd) N (Rd) 2 , N (Rd) S (O) tRd, S (O) tORd, S (O) tN (R
