Transdermal Therapeutic system with at least one Solid Matrix monolayer containing a Polymer Matrix and / or oversaturated with gestodene ethinyl estradiol and a removable Protective Film AdyaCenter, which not recristaliza recristaliza or less than 2% of the surface of the Patch of proportion not dissolved in the polymer Matrix.
The invention relates to pharmaceutical formulations, in particular to transdermal therapeutic systems, which are characterized in that little or no active ingredient crystallizes out at the interface between the removable protective film (release liner) and the active-ingredient-containing matrix.SISTEMA TERAPEUTICO TRANSDERMICO SOLIDO CON AL MENOS UNA MATRIZ MONOCAPA QUE CONTIENE UN POLIMERO DE MATRIZ SOBRESATURADO CON GESTODENO Y/O ETINILESTRADIOL, Y UNA LAMINA DE PROTECCION DESPRENDIBLE ADYACENTE, DONDE LA MATRIZ CONTIENE POLIISOBUTILENO Y ESTA LIBRE DE DILUYENTES Y DISPERSANTES; KIT.