attenuated virus, attenuated arbovirus, its uses, vaccine composition, method of producing an attenuated virus genome, method of producing an attenuated arbovirus, and attenuated arbovirus genome
THE RESEARCH FOUNDATION FOR THE STATE UNIVERSITY OF NEW YORK
发明人:
BRUCE FUTCHER,CHARLES STAUFT,CHARLES WARD,ECKARD WIMMER,SAM SHEN,STEFFEN MUELLER
申请号：
BR112017004452
公开号：
BR112017004452A2
申请日:
2015.09.08
申请国别(地区):
BR
年份:
2018
代理人:
摘要：
This invention provides an attenuated virus comprising a modified viral genome engineered to containing multiple nucleotide substitutions that reduce the codon pair bias of a virus protein encoding sequence relative to a first host while the codon pair bias relative to a second host is not substantially reduced. In another embodiment, the invention provides an attenuated virus comprising modified viral genome engineered to containing multiple nucleotide substitutions that reduce the codon pair bias of a virus protein-encoding sequence relative to a first host and a second host. The attenuated virus may be used in a vaccine composition for inducing a protective immune response in a subject. The invention also provides a method of synthesizing the attenuated virus. Further, this invention further provides a method for preventing a subject from becoming afflicted with a virus-associated disease comprising administering to the subject a prophylactically effective dose of a vaccine composition comprising the attenuated virus.
