The United States of America as Represented by the Secretary of the Dept. of Health and Human;COLORADO SEMINARY, WHICH OWNS AND OPERATES THE UNIVERSITY OF DENVER
发明人:
Eric BERGERON,Scott Dusan PEGAN,Stuart T. NICHOL,Michelle Kay DEATON
申请号：
US14421120
公开号：
US20150306202A1
申请日:
2013.08.13
申请国别(地区):
US
年份:
2015
代理人:
摘要：
The genetically modified nairoviruses of this invention possesses a viral ovarian tumor protease with decreased ability to remove ubiquitin (Ub) and ISG15 tags that the human organism uses to label proteins for removal. Exemplary are Crimean-Congo hemorrhagic fever virus and Erve virus. Unlike complete knockout strains, the modified virus retains enough activity for replication in a human cell line. This creates an immunogenic and non-pathogenic virus that can be used as an effective live vaccine agent for prophylaxis and treatment.
