COLORADO SEMINARY WHICH OWNS AND OPERATES THE UNIVERSITY OF DENVER
发明人:
BERGERON, ERIC,PEGAN, SCOTT DUSAN,NICHOL, STUART T.,DEATON, MICHELLE KAY
申请号：
EP13829120
公开号：
EP2884998A4
申请日:
2013.08.13
申请国别(地区):
EP
年份:
2016
代理人:
摘要：
The genetically modified hemorrhagic fever virus of this invention possesses a viral ovarian tumor protease with decreased ability to remove ubiquitin (Ub) and ISG15 tags that the human organism uses to label proteins for removal. Unlike complete knockout strains, the modified virus retains enough activity for replication in a human cell line. This creates an immunogenic and non-pathogenic virus that can be used as an effective live vaccine agent.
