The present invention relates to novel pharmaceutical and cosmetic formulations with antiacne activity containing: a) an antimicrobial hydrophilic extract of Krameria sp., or a pure compound from said extract and/or an antimicrobial lipophilic extract of Mesua ferrea; b) ximeninic acid and/or lauric acid; c) anti-inflammatory saponins extracted from Olax dissitiflora, Aesculum hippocastanum, Centella asiatica, Terminalia sericea, Glycyrrhiza glabra.