PYRIMIDINES POLYSUBSTITUEES INHIBANT LA FORMATION DE PROSTAGLANDINE E2, LEUR PROCEDE DE PRODUCTION ET LEUR UTILISATION

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专利权人:

USTAV ORGANICKE CHEMIE A BIOCHEMIE AV CR, V.V.I.;USTAV EXPERIMENTALNI MEDICINY AV CR, V.V.I.

发明人:

KOLMAN, VIKTOR,KALCIC, FILIP,JANEBA, ZLATKO,ZIDEK, ZDENEK

申请号：

CA3058795

公开号：

CA3058795A1

申请日:

2018.05.23

申请国别(地区):

CA

年份:

2018

代理人:

摘要：

The invention describes the pyrimidine-based compounds of the general formula I. Described compounds lower the production of the prostaglandin E2. In concentrations lowering production of this factor by 50%, these compounds have no negative effect on the cell viability and they are not cytotoxic. Furthermore, the method of production of the compounds of the general formula I is provided. A pharmaceutical composition comprising the polysubstituted pyrimidines according to the invention and the use of these compounds for the treatment of the inflammatory diseases are also provided.

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