Petr Jansa,Antonin Holy,Zdenek Zidek,Eva Kmonickova,Zlatko Janeba
申请号：
US14000461
公开号：
US08883798B2
申请日:
2012.02.27
申请国别(地区):
US
年份:
2014
代理人:
摘要：
The invention provides pyrimidine compounds of general formula (I), which reduce simultaneously the production of nitric oxide (NO) and prostaglandin E2 (PGE2). They have no negative effect on the viability of cells in concentrations decreasing the production of these factors by up to 50%； they are not cytotoxic. Furthermore, a method of preparation of the pyrimidine compounds of general formula (I), carrying 2-formamido group, a pharmaceutical composition comprising the substituted pyrimidine compounds according to the invention, and the use of these compounds for the treatment of inflammatory and cancer diseases are provided.
