U.S. ARMY MEDICAL RESEARCH INSTITUTE OF INFECTIOUS DISEASES； DEPARTMENT OF THE ARMY
发明人:
申请号：
EP03813037.3
公开号：
EP1529107B1
申请日:
2003.03.21
申请国别(地区):
EP
年份:
2012
代理人:
摘要：
In this application is described a protective DNA vaccines against infection with HFRS- and HPS-associated hantaviruses. The vaccines were constructed by subcloning cDNA representing the medium (M) (encoding the G1 and G2 glycoproteins) into the DNA expression vector pWRG7077. Animals vaccinated with the M construct developed a neutralizing antibody response. Passive transfer experiments show that serum from vaccinated animals, when injected on days 4 or 5 after challenge, protected animals from lethal disease.
