A device for cleaning a site of a luer activated valve (LAV) is disclosed. The device can include a cap having an inner cavity for receiving a site of the LAV. The cap can be formed to provide at least one aperture to the inner cavity when the site is received into the inner cavity. The device can also include one or more protrusions that extend inwardly from the cap to engage the site to maintain the cap on the site. The device can also include a cleaning agent that occupies some of the inner cavity. The cleaning agent can be formulated to clean the site as the inner cavity receives the site and when the cap is maintained on the site. The device can further include a removable seal that seals the cleaning agent within the inner cavity prior to the inner cavity of the cap receiving the site.
