A cleaning device for a site of a medical implement is disclosed. The cleaning device can include a cap having an opening to an inner cavity, and the opening can be adapted to receive a site of the medical implement. The inner cavity can include a male luer protrusion that extends up from an inner wall toward the opening, and can be sized and adapted for insertion into a female luer when the cap is provided on the medical implement. The cleaning device can further include a cleaning material that contains a cleaning agent prior to receipt of the site of the medical implement, i.e. the cleaning material is pre-loaded with the cleaning agent, to swab and clean the site with the cleaning agent. The cap can further include a friction-forming member for creating a friction-based fitting of the cap onto the site of the medical implement.
