A cleaning device for a site of a medical implement is disclosed, as are methods for using such devices. The cleaning device can include a cap having an opening to an inner cavity, and the opening can be adapted to receive a site of the medical implement. The inner cavity can include a male luer protrusion that extends up from an inner wall toward the opening, and can be sized and adapted for insertion into a female luer when the cap is provided on the medical implement. The cleaning device can further include a cleaning material that contains a cleaning agent prior to receipt of the site of the medical implement, i.e. the cleaning material is pre-loaded with the cleaning agent. The cleaning material can be at least partially secured in the inner cavity and adapted to swab and clean the site with the cleaning agent. The cap can further include a friction-forming member for creating a friction-based fitting of the cap onto the site of the medical implement.
