P. Jeffrey Conn,Craig W. Lindsley,Shaun R. Stauffer,José Manuel Bartolomé-Nebreda,Susana Conde-Ceide,Gregor James Macdonald,Han Min Tong,Miguel Angel Pena-Piñón,Manuel Jesús Alcázar-Vaca,José Ignacio
申请号：
US13922230
公开号：
US08901125B2
申请日:
2013.06.19
申请国别(地区):
US
年份:
2014
代理人:
摘要：
In one aspect, the invention relates to substituted bicyclic alkoxy pyrazole analogs, derivatives thereof, and related compounds, which are useful as positive allosteric modulators of the metabotropic glutamate receptor subtype 5 (mGluR5)； synthetic methods for making the compounds； pharmaceutical compositions comprising the compounds； and methods of treating neurological and psychiatric disorders associated with glutamate dysfunction using the compounds and compositions. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.
