Conn, Jeffrey P.,Lindsley, Craig W.,Stauffer, Shaun R.,Bartolome-Nebreda, Jose Manuel,Macdonald, Gregor James,Conde-Ceide, Susana,Tong, Han Min,Pena-Pinon, Miguel Angel,Alcazar-Vaca, Manuel Jesus,Andr
申请号:
AU2013277152
公开号:
AU2013277152A1
申请日:
2013.06.19
申请国别(地区):
AU
年份:
2015
代理人:
摘要:
In one aspect, the invention relates to substituted bicyclic alkoxy pyrazole analogs, derivatives thereof, and related compounds, which are useful as positive allosteric modulators of the metabotropic glutamate receptor subtype 5 (mGluR5); synthetic methods for making the compounds; pharmaceutical compositions comprising the compounds; and methods of treating neurological and psychiatric disorders associated with glutamate dysfunction using the compounds and compositions. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.